A new UK study has found that one in three corona infected patients may develop long-Covid symptoms. This is around 37 per cent of the total corona infected patients. These long-Covid symptoms are diagnosed in the three to six month period. The most common long-Covid symptoms were breathing problems, abdominal symptoms, fatigue, pain and anxiety/depression.
The research from the University of Oxford and the National Institute for Health Research (NIHR) Oxford Health Biomedical Research Centre (BRC) investigated long-Covid in over 270,000 people recovering from Covid-19 infection, using data from the US-based TriNetX electronic health record network. “The results confirm that a significant proportion of people, of all ages, can be affected by a range of symptoms and difficulties in the six months after Covid-19 infection,” said NIHR Academic Clinical Fellow Dr Max Taquet, who led the analysis at the University of Oxford.
Why long-Covid symptoms occur?
“These data complement findings from self-report surveys, and show that clinicians are diagnosing patients with these symptoms. We need appropriately configured services to deal with the current and future clinical need, said Taquet.
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The study finds that higher rates were seen if the whole 1-180 day period after a Covid-19 infection was included. Severity of infection, age, and sex affected the likelihood of long-Covid symptoms: long-Covid symptoms were more frequent in those who had been hospitalized, and they were slightly more common in women. These factors also influenced which of the symptoms people were most likely to experience.
For example, older people and men had more breathing difficulties and cognitive problems, whereas young people and women had more headaches, abdominal symptoms and anxiety/depression. Many patients had more than one long-Covid symptom, and symptoms tended to co-occur more as time progressed.
Why doesn’t everyone recover rapidly?
“Research of different kinds is urgently needed to understand why not everyone recovers rapidly and fully from Covid-19, said Professor Paul Harrison, who headed the study, Department of Psychiatry, University of Oxford. “We need to identify the mechanisms underlying the diverse symptoms that can affect survivors. This information will be essential if the long-term health consequences of Covid-19 are to be prevented or treated effectively, he said. Basically, these observations were being made to understand the long-Covid symptoms’ occurrence in corona affected patients.
The study also looked at the same symptoms in people recovering from influenza or flu. Long-Covid symptoms did occur after influenza, but were 1.5 times more common after Covid-19.
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According to the findings, the nine core long-Covid symptoms, occurring 90-180 days after Covid-19 was diagnosed, comprise: Abnormal breathing (8 per cent); abdominal symptoms (8 per cent); anxiety/depression (15 per cent); chest/throat pain (6 per cent); cognitive problems or so-called brain fog (4 per cent); fatigue (6 per cent); headache (5 per cent); myalgia or muscle pain (1.5 per cent); other pain (7 per cent); and any of the above features (37 per cent).
The study highlights that it does not explain what causes long-Covid symptoms, nor how severe they are, nor how long they will last. The results do not take into account people who had Covid-19 but were not diagnosed, for example because they were asymptomatic and did not get tested, nor Covid-19 survivors with long-Covid symptoms that had not been recorded in their health records.